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Acute Brain and Cardiovascular Injury

Head
Elisa
R. Zanier
Head of Department
Dipartimento di Ricerca Danno Cerebrale e Cardiovascolare Acuto
elisa.zanier@marionegri.it
Staff
Aurora
Chiapperini
Department Assistant
Dipartimento di Ricerca Danno Cerebrale e Cardiovascolare Acuto
aurora.chiapperini@marionegri.it
Senior Advisor
Roberto
Latini
Senior Advisor
Dipartimento di Ricerca Danno Cerebrale e Cardiovascolare Acuto
roberto.latini@marionegri.it

The Department of Acute Brain and Cardiovascular Injury investigates brain and cardiological conditions, including epilepsia, traumatic brain injury, stroke and cardiac arrest aiming at improving the disease course and prognosis.

Brain and vascular damage associated with these conditions leads to severe chronic cognitive and/or motor impairment and/or recurrent epileptic seizures in a high percentage of patients.

Developing therapies for these patients is, therefore, a priority.

ObJECTIVES

The aim of the Department is to develop preclinical models and foster the interaction between laboratory and clinical activities, to:

  • Describe the pathogenic mechanisms of acute brain and cardiovascular injuries, define disease-associated endophenotypes and identify potential drug targets;
  • Develop therapies for acute brain and cardiovascular damage and its chronic sequelae;
  • Establish a preclinical biorepository in line with the goal of identifying new biomarkers, or exploring new mechanisms by reducing the use of animals for research;
  • Contribute to the scientific training of early career basic scientists and clinicians in the field of critical care and neuroscience.

METHODOLOGICAL APPROACHES

  • In vitro and in vivo models of acute brain injuries;
  • Histological, biochemical and molecular biology approaches;
  • Brightfield, confocal and super-resolution microscopy techniques;
  • Processing and analysis of brain images from in vivo nuclear magnetic resonance and microscopy;
  • Analysis of biomarkers by ultra-sensitive techniques;
  • Video-electroencephalography and electrophysiology;
  • High definition ecocardiography, electrocardiogram and invasive hemodynamics
  • Behavioral tests;
  • Development of cell therapies in both experimental and clinical settings;
  • Phase I-II clinical trials in the field of cardiovascular medicine, epilepsy and traumatic brain injury.
  • Observational studies in collaboration with a large network of general practitioners
  • ISO9001 certified Biobank, whose material derives from different patient cohorts, for a total of more than 30000 subjects
Results
  • Identification of new biomarkers and systemic drug targets for ischemic stroke;
  • Development of cell therapy for severe traumatic brain injury.
  • Halving of heart attack related mortality – GISSI study, performed with the participation of 90% of Italian Coronary Units
  • Identification of new genes responsible for the development of coronary heart disease

Current projects


 
Prospective preclinical and clinical studies of gut microbiota, intestinal barrier, and related blood metabolites, following traumatic brain injury for developing prognostic biomarkers of chronic neurological sequelae, and for identifying targets to prevent the progressive evolution of brain injury and the chronic disabilities

Sponsor: Ministero della Salute - Unione Europea (NextGenerationEU-2-0069)

Research Area: Trauma cranico, microbiota

TBI-ADRD Modeling with a Team Science Approach (TBI-ADRD Team Science)

Sponsor: National Institutes of Health (NIH), USA-funded study

Research Area: Trauma cranico, malattia di Alzheimer

Ficolin-2-dependent mechanisms of morpho-functional evolution of unstable atherosclerotic plaques (FUN AT PLAQUE)

Sponsor: Fondazione Regionale per la Ricerca Biomedica (FRRB), Regione Lombardia

Research Area: Malattie cardiovascolari, aterosclerosi

Natural history of familial cerebral cavernous malformations: the CCM_Italia cohort study

Sponsor: Ministero della Salute – Bando PNRR 2023

Research Area: Malattie rare

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Head
Elisa
R. Zanier
Head of Department
Dipartimento di Ricerca Danno Cerebrale e Cardiovascolare Acuto
elisa.zanier@marionegri.it
Staff
Aurora
Chiapperini
Department Assistant
Dipartimento di Ricerca Danno Cerebrale e Cardiovascolare Acuto
aurora.chiapperini@marionegri.it
Senior Advisor
Roberto
Latini
Senior Advisor
Dipartimento di Ricerca Danno Cerebrale e Cardiovascolare Acuto
roberto.latini@marionegri.it

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