The Department of Acute Brain and Cardiovascular Injury investigates brain and cardiological conditions, including epilepsia, traumatic brain injury, stroke and cardiac arrest aiming at improving the disease course and prognosis.
Brain and vascular damage associated with these conditions leads to severe chronic cognitive and/or motor impairment and/or recurrent epileptic seizures in a high percentage of patients.
Developing therapies for these patients is, therefore, a priority.
The aim of the Department is to develop preclinical models and foster the interaction between laboratory and clinical activities, to:
Functional and structural cerebrovascular alterations in neurological disorders: the role of complement (VASCO)
Sponsor: Fondazione Regionale per la Ricerca Biomedica, Regione Lombardia
Research Area: Neuroinfiammazione e ictus ischemico
Blood markers of post-traumatic epilepsy prediction and electrophysiological biomarkers of early PTE detection
Sponsor: Department of Defense, USA-funded study (W81XWH-15-2-0069
Research Area: Trauma cranico, epilessia e neuroinfiammazione
Early mechanistic BIOmarkers for late Epilepsy and long-term Brain Injury Outcome
Sponsor: ERA-NET NEURON (Call for Joint Transnational Research Projects 2019, TRANSLATIONAL BIOMARKERS IN BRAIN DISORDERS)
Research Area: Epilessia e neuroinfiammazione
Prospective preclinical and clinical studies of gut microbiota, intestinal barrier, and related blood metabolites, following traumatic brain injury for developing prognostic biomarkers of chronic neurological sequelae, and for identifying targets to prevent the progressive evolution of brain injury and the chronic disabilities
Sponsor: Ministero della Salute - Unione Europea (NextGenerationEU)-2-0069)
Research Area: Trauma cranico, microbiota
Mesenchymal stromal cells for TBI – clinical trial
Sponsor: Fondazione regionale per la ricerca (FRRB) e Ministero della Salute Ricerca Finalizzata
Research Area: neuroprotezione e trauma cranico
Progetti di Rete IRCCS - Rete Cardiologica - Digital strategies in primary cardiovascular prevention in the Italian population (CV PREVITAL)
Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità
Research Area: Prevenzione cardiovascolare
Mechanisms accounting for brain protection by argon following resuscitation from cardiac arrest
Sponsor: Laerdal Foundation, Norvegia
Research Area: Danno cerebrale dopo arresto cardiaco
Improving outcomes in cardiac arrest and cardiopulmonary resuscitation with kynurenine pathway inhibition
Sponsor: European Society of Anaesthesiology - ESA AISBL, Belgio
Research Area: Arresto cardiaco
Ricerca Finalizzata - RF-2016-02364318 - Selection of people at low cardiovascular risk: development of an inexpensive pre-screening algorithm using only non-laboratory measures. The SKIM risk study
Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità
Research Area: Rischio cardiovascolare
Ricerca Finalizzata - RF-2016-02361583 - Efficacy of Albumin Replacement and Balanced Crystalloid Solutions in Septic Shock (the ALBIOSS-BALANCED trial): a 2-by-2 factorial, investigator-initiated, open-label, multicenter, randomized, controlled trial
Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità
Research Area: Shock Settico
Progetti di Rete IRCCS - Rete Cardiovascolare - Implementation of mobile Health and eHealth approaches for optimal cardiovascular prevention - IMPROVE Study
Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità
Research Area: Prevenzione cardiovascolare
SECURE - Secondary Prevention of Cardiovascular Disease in the Elderly, a prospective randomized clinical trial comparing a polypill versus standard of care treatment strategies in post MI elderly patients
Sponsor: Commissione Europea
Research Area: Malattie Cardiovascolari
ESCAPE-NET - European Sudden Cardiac Arrest network: towards Prevention, Education and NEw Treatment
Sponsor: Commissione Europea
Research Area: Malattie Cardiovascolari
Treat_CCM Clinical Trial - A multicenter randomized clinical trial on Propranolol in Cerebral Cavernous Malformation (CCM)
Sponsor: Agenzia Italiana del Farmaco AIFA
Research Area: Malattie rare, CCM
The Research Center for Amyotrophic Lateral Sclerosis (ALS Center) brings together the groups that are involved in ALS research from an epidemiological, preclinicaland translational point of view.